ea0081p396 | Pituitary and Neuroendocrinology | ECE2022
Maria Berton Alessandro
, Prencipe Nunzia
, Bertero Luca
, Corsico Marina
, Cuboni Daniela
, Baldi Marco
, Bima Chiara
, Bianchi Antonio
, Mantovani Giovanna
, Ferrau Francesco
, SARTORATO PAOLA
, Gagliardi Irene
, Grottoli Silvia
Introduction: First-generation SRL (fg-SRL) represent the treatment of choice in acromegaly patients with post-neurosurgical adenomatous remnant and GH-hypersecretion. Anyway, approximately 60% of patients do not achieve adequate disease control. The main predictors of resistance include male sex, young age, invasiveness of the lesion and its hyperintensity on T2-weighted MRI scans; but also, SSTR2 expression, the cytokeratin pattern, Ki-67 and the presence of AIP gene mutatio...